Glomerular Filtration Rate in Prediabetic Subjects in Kendari City

  • Theosobia Grace Orno Poltekkes Kemenkes Kendari
  • Ratih Feraritra Danu Atmaja
  • Supiati Supiati
  • Aswiro Hasan
Keywords: glomerular filtration rate;, prediabetic;, fasting blood glucose;, oral glucose tolerance test

Abstract

Prediabetes is a condition of impaired blood glucose metabolism. However, it does not yet meet the criteria for diabetes mellitus, characterized by impaired fasting blood glucose (FBG) levels and the Oral Glucose Tolerance Test (OGTT). Chronic glucose intolerance can increase the workload of the kidney glomerulus in the filtration process and the tubules in the reabsorption process. The research aims to assess the Glomerular Filtration Rate (GFR) in prediabetic subjects in Kendari. This type of analytical observational research with a case-control design. The total sample was 90 samples consisting of 45 non-diabetic samples as the control group and 45 prediabetic samples as the case group. Characteristic data is presented as a frequency distribution and test data for differences between the control group and cases using an independent t-test with statistical test results said to be significant if the p-value is less than 0.05. The research results showed that the frequency distribution of subjects in the control group and cases based on gender was dominated by women, with the most extensive age range being 36-55 years. The FBG variable in the control group had a mean of 94±5.31 mg/dL, and in the case group, 110±8.09 mg/dL. The OGTT value in the control group was 118±12.78 mg/dL, and the case group was 139±23.90 mg/dL. The results of the calculation of the GFR showed a mean of 98.63±14.28 mL/min/1.73 m2 in the control group and 50.10±16.34 mL/min/1.73 m2 in the case group, different significant (p equal 0.000). There was a significant difference between GFR in the control group and the prediabetes case group. The results of the GFR assessment in the prediabetes group showed a mild decrease in renal function.

References

1. World Health Organization, World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: World Health Organization, 2006: 1-50.
2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37 Suppl 1: S81-S90 [PMID: 24357215 DOI: 10.2337/dc14-S081]
3. Perkumpulan Endokriologi Indonesia. Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia, PB Perkeni, 2021
4. Centers for Disease Control and Prevention. National Diabetes Statitiscs Report: Estimates of Diabtes and Its Burden in the United States, Atlanta, GA: US Department of Health and Human Services, 2014
5. Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J: Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes 54:3427–3434, 2005
6. Mogensen CE: Maximum tubular reabsorption capacity for glucose and renal hemodynamics during rapid hypertonic glucose infusion in normal and diabetic subjects. Scand J Clin Lab Invest 28:101– 109, 1971
7. Calado J, Santer R, Rueff J: Effect of kidney disease on glucose handling (including genetic defects). Kidney Int Suppl 120:S7–S13, 2011
8. Mather A, Pollock C: Glucose handling by the kidney. Kidney Int Suppl 120:S1–S6, 2011
9. Takenouchi, Akiko dkk. Direct Association of Visit to visit HbA1c Variation with Annual Decline in Estimated Glomerular Filtration Rate in Patients with Type 2 Diabetes. Journal of Diabetes & Metabolic Disorders: 14(69):1-7, 2015
10. Basundoro, P. A., & Adhipireno, P. Hubungan Kadar Glukosa Darah Terhadap Estimasi Laju Filtrasi Glomerulus Pada Pasien Diabetes Melitus. Diponegoro Medical Journal. (Jurnal Kedokteran Diponegoro), 6(2), 1027-1034, 2017, https://doi.org/10.14710/dmj.v6i2.18614
11. Driyah, S., & Pradono, J. Korelasi Hemoglobin A1c dengan Hemoglobin dan Laju Filtrasi Glomerulus Penderita Diabetes dengan dan Tanpa Komplikasi Gagal Ginjal Kronik di Bogor. Media Penelitian dan Pengembangan Kesehatan. Litbangkes RI. 2021. https://doi.org/10.22435/mpk.v30i4.3174
12. Driyah, S., dkk. Prediktor sindrom metabolik: Studi kohor perspektif selama enam tahun di Bogor, Indonesia. Media Litbangkes, Vol.29 No.3, September 2019,215–224. https://doi.org/10.22435/mpk.v29i 3.654
13. Persatuan Diabetes Indonesia, & Perkumpulan Endokriologi Indonesia. Pedoman pengolaan dan pencegahan prediabetes di Indonesia, 2019, Surabaya.
14. Eknoyan G, Lameire N, Barsoum R, et al. The burden of kidney disease: improving global outcomes. Kidney Int. 2004;66(4):1310-1314. doi:10.1111/j.1523-1755.2004.00894.x
15. Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, Bernardi L, Valensi P; Toronto Diabetic. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care 2010; 33: 2285- 2293 [PMID: 20876709 DOI: 10.2337/ dc10- 1303]
16. Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck-Nielsen H, Mari A; RISC Investigators. Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study. Diabetologia. 2011;54(6):1507–16
17. Perreault L, Pan Q, Mather KJ, Watson KE, Hamman RF, Kahn SE; Diabetes Prevention Program Research Group. Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes Study. Lancet. 2012;379(9833):2243–51
18. DeFronzo RA, Davidson JA, del Prato S: The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab 14:5–14, 2012
Published
2024-04-25
How to Cite
1.
Orno TG, Atmaja RFD, Supiati S, Hasan A. Glomerular Filtration Rate in Prediabetic Subjects in Kendari City. woh [Internet]. 2024Apr.25 [cited 2024May23];:187-93. Available from: https://jurnal.fkmumi.ac.id/index.php/woh/article/view/917
Section
Articles