The Effect of Aloe Vera Tea on Constipation Management And Safety of Fetal Growth

Nurul Arriza; Andi Nilawati  Usman; Healthy Hidayanty; Mardiana  Ahmad; Risfa Yulianty; Irmayanti

doi:10.33096/woh.v7i2.297

Nurul Arriza Midwifery Masters Study Program, Postgraduate School, Hasanuddin University
Andi Nilawati Usman Midwifery Masters Study Program, Postgraduate School, Hasanuddin University
Healthy Hidayanty Nutrition Study Program, Faculty of Public Health, Hasanuddin University
Mardiana Ahmad Midwifery Masters Study Program, Postgraduate School, Hasanuddin University
Risfa Yulianty Study Program, Faculty of Pharmacy, Hasanuddin University
Irmayanti Faculty of Nursing, Kyung Pook National University, South Korea

DOI: https://doi.org/10.33096/woh.v7i2.297

Keywords: Aloe vera, Aloin, Constipation, Laxative, Fetus

Abstract

Constipation is one of the 60% of gastrointestinal discomforts in pregnancy. WHO (2018) states that 11-38% of pregnancies will experience constipation. It takes laxative substances that stimulate peristaltic movement of the intestinal wall, such as aloe vera. However, it contains a teratogenic component for pregnant women, namely aloin. The study aims to determine the effect of aloe vera tea as a treatment for constipation and test fetal weight growth's safety during organogenesis. Methods: This research is an experimental study, a laboratory pre-clinical study using a pre-post test randomized control group design in-vivo method. Against 24 pregnant mice constipated by induced oral extract of gambier 1 ml. Results: The control group intervention (Dulcolax 0.1 ml/20grBB) had a higher mean frequency than the aloe vera tea treatment. The results of the ANOVA test of 0.013<0.05 showed a significant difference between the four groups after five days. The category of the fastest onset of action of laxatives was shown in K3 (aloe vera tea dose of 0.2gr/20grBB) at 03:08 minutes compared to the control group (Dulcolax 0.1gr/20grBB) at 04:35 minutes. The ANOVA test of 0.000<0.05 showed a significant difference between K1, K2, K3 and K4. Based on the weight of the fetuses from the four groups was not significantly different (0.764>0.05). Conclusion: Dulcolax 0.1 ml and aloe vera tea 0.2gr/20grBB effectively increased the frequency of defecation in mice. Aloe vera tea 0.2gr/20grBB was very effective, with the fastest onset of laxative action compared to the control group. Aloe vera tea affects fetal growth in the form of a decrease in body weight at the highest dose of 0.4gr/20grBB. Suggestion: A dose of 0.2 grams of aloe vera tea is recommended to be converted to a human dose as an effective measure for treating constipation in pregnant women.

References

1. Ojieh AE. Constipation In Pregnancy And The Effect Of Vegetable Consumption In Different Socio – Economic Class In Warri, Delta State. J Med Appl Biosci Cenresin Publ www.cenresin.org ISSN 2277-0054. 2012;4(June):1–6.
2. Hanim B. Analisis Penyebab Konstipasi Pada Ibu Hamil Di Wilayah Kerja Puskesmas Payung Sekaki Pekanbaru. 2019;
3. Sembiring LP. Konstipasi Pada Kehamilan. J Ilmu Kedokteran. 2017;9(1):7.
4. Karyati S. Hubungan Pola Aktivitas Fisik Dengan Konstipasi Pada Ibu Hamil Trimester Iii Di Puskesmas Gribig Kecamatan Gebog Kabupaten Kudus Tahun 2017. J Ilmu Keperawatan dan Kebidanan. 2019;10(2):350–7.
5. Shimoyama T, Takahashi R, Kimura M, Fukuda Y. Study of the mechanisms of a Japanese traditional. J Gastroenterol Hepatol 2015; 30 (Suppl 1) 53–59. 2015;30:53-59 doi:10.1111/jgh.12741.
6. Johnson P, Mount K, Graziano S. Functional bowel disorders in pregnancy : effect on quality of life , evaluation and management. Nord Fed Soc Obstet Gynecol Acta Obstet Gynecol Scand. 2014;93:874-879 DOI: 10.1111/aogs.12434.
7. McRorie JW, Fahey GC, Gibb RD, Chey WD. Laxative Effects Of Wheat Bran And Psyllium: Resolving Enduring Misconceptions About Fiber In Treatment Guidelines For Chronic Idiopathic Constipation. J Am Assoc Nurse Pract. 2020;32(1):15–23.
8. Markland AD, Palsson O, Goode PS, Burgio KL, Busby-Whitehead J, Whitehead WE. Association of low dietary intake of fiber and liquids with constipation: Evidence from the national health and nutrition examination survey. Am J Gastroenterol. 2013;108(5):796–803.
9. Hong SW, Chun J, Park S, Lee HJ, Im JP, Kim JS. Aloe vera is effective and safe in short-term treatment of irritable bowel syndrome: A systematic review and meta-analysis. J Neurogastroenterol Motil. 2018;24(4):528–35.
10. Sajjad A, Subhani Sajjad S. Aloe vera : An Ancient Herb for Modern Dentistry—A Literature Review . J Dent Surg. 2014;2014:1–6.
11. Joseph B, Raj SJ. Pharmacognostic And Phytochemical Properties Of Aloe Vera Linn – An Overview Taxonomy : Enzymes : 2011;4(2):106–10.
12. Srivastava R, Jyoti B, Pathak S, Shukla A, Sajid Z. Aloe Vera : The Herbal Magic Wand. 2014;300(September).
13. Onainor ER. Analisis Perkembangan Fetus Mencit Terpapar Teratogenesis. 2019;1:105–12.
14. Busman H, Nurcahyani N, Saputra YD, Farisi S, Salsabila Q. Mortalitas Dan Resorpsi Fetus Mencit (Mus Musculus L.) Setelah Pemberian Ekstrak Etanol Tanaman Suruhan (Peperomia Pellucida (L.,) Kunth.). J Kesehat Kusuma Husada. 2021;12(2):194–202.
15. Singchai B, Kansane K, Chourykaew B. Phytochemical screening and biological activities of borassus flabellifer L. Asian J Pharm Clin Res. 2015;8(3):151–3.
16. Guo X, Mei N. Aloe vera: A review of toxicity and adverse clinical effects. J Environ Sci Heal - Part C Environ Carcinog Ecotoxicol Rev [Internet]. 2016;34(2):77–96. Available from: http://dx.doi.org/10.1080/10590501.2016.1166826
17. Kristian A. Uji teratogenik ekstrak etanol daun alpokat (persea Americana Mill) pada mencit betina (mus musculus). J Ilm Mhs Univ Surabaya. 2013;2(1):1–15.
18. James L. Hutchinson M, San Mateo C. THE LAXATIVE. 2013;95(5):399–400.
19. alfi ramadhanti. Efek Laksatif Ekstrak Lidah Buaya (Aloe Barbadensis Miller) Pada Mencit Putih Jantan (Mus Musculus). 2016;147:11–40.
20. Keraru EN. Pengaruh Pemberian Dosis Seduhan Bubuk Kopi Robusta (Coffea Canephora) Maggarai Terhadap Efek Laksatif Pada Tikus Putih Betina. 2017;
21. Wei Zxfp. Glukomanan Untuk Konstipasi. 2019;26(19):1–9.
22. Ji Franco Han. Klasifikasi Kelompok Laksatif. 2015;
23. Sari AR, Mardhiyah EN, Hendrawati TY, Teknik F, Jakarta UM, Putih C, et al. Pembuatan Teh Aloe Vera dan Daun Stevia sebagai Potensi untuk Pencahar. 2020;
24. Chabib L, Indrati O, Rizki MI. Formulasi Tablet Effervescent Ekstrak Lidah Buaya (Aloe vera). J Pharmascience. 2015;2(1):72–80.
25. Ritter.M.James. Pharmacology Rang And Dale’s. 2012.
26. Chalik R. Endokrinologi Dan Anatomi Fisiologi Manusia. 2016;1.
27. Veterinus Im, Mutiarahmi Cn, Hartady T, Lesmana R. Kajian Pustaka : Penggunaan Mencit Sebagai Hewan Coba Di Laboratorium Yang Mengacu Pada Prinsip Kesejahteraan Hewan. 2021;10(1):134–45.
28. Yulianadevianti. Uji Efek Laksatif Ekstrak Etanol Buah Pepino (Solanum Muricatum Aiton.) Pada Tikus Jantan Galur Wistar Dengan Metode Transit Intestinal. 2017;87(1,2):149–200.
29. Vakili M, Ahmadipour S, Rahmani P. Concise review: Herbal remedies and herbal plants for constipation in children. Biomed Res Ther. 2018;5(5):2260–7.
30. Hung Myeec. A Review On The Relationship Between Aloe Vera Components And Their Biologic Effects. Semin Integr Med Vol 1, No 1 (March),. 2013;1(1):53–62.
31. Bernstein N, Akram M, Yaniv-Bachrach Z, Daniyal M. Is It Safe To Consume Traditional Medicinal Plants During Pregnancy? Phyther Res. 2021;35(4):1908–24.
32. Setiatin Et, Rosadi B, Hine Tm. Performansi Reproduksi Tikus Betina Dengan Effect Of Aloe Vera Gel Administrated On Reproductive Performance Of Female Rats. J Kedokt Hewan. 2017;1(1):1–6.
33. Soenardirahardjo P. Teratologi Pada Hewan Dan Ternak. 2017;1–21.
34. Mathur P, Choudhary S, Bhatnagar P. Aloe Vera Protects Against Fluoride-Induced Teratogenic Effects During Pre- And Postnatal Development In Mice. Environ Sci Pollut Res. 2022;1–9.
35. Poernomo B. Potensi paparan teratogenesis untuk menghindari kejadian cacat lahir pada hewan. Simp Build Golden Gener. 2017;
36. Dillasamola D, A A, Desri A, Diliarosta S. Uji Efek Teratogenik dari Yoghurt Terhadap Fetus Mencit Putih (Mus musculus). J Sains Farm Klin. 2018;5(1):28.
37. Setyawati I, Yulihastuti DA. Reproductive Performance And Foetus Skeletal Development Of Mice After Treated By Young Pineapple Fruit Extract. 2011;12(3):192–9.
38. Almahdy A, Almunawwarah Na, Fitria N. Uji Efek Teratogen Kakao Bubuk Pada Fetus Mencit Putih. Jstfi Indones J Pharm Sci Technol. 2013;2(1):9–26.
39. Rubiyati, Setiawan A. Terhadap Perkembangan Fetus Mencit ( Mus Musculus L .) Swiss. J Akad Baiturrahim. 2016;5(1):1–13.
40. Flores-López ML, Romaní A, Cerqueira MA, Rodríguez-García R, Jasso de Rodríguez D, Vicente AA. Compositional features and bioactive properties of whole fraction from Aloe vera processing. Ind Crops Prod [Internet]. 2016;91:179–85. Available from: http://dx.doi.org/10.1016/j.indcrop.2016.07.011
41. Kumar S, Yadav A, Yadav M, Yadav JP. Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f. BMC Res Notes. 2017;10(1):1–12.
42. Swami Hulle NR, Chakraborty S, Rao PS. Effect of high pressure thermal processing on the quality attributes of Aloe vera-litchi mixed beverage [Internet]. Vol. 40, Innovative Food Science and Emerging Technologies. Elsevier B.V.; 2017. 68–77 p. Available from: http://dx.doi.org/10.1016/j.ifset.2016.07.025
43. Fatimah S, Anjani G. Aktivitas Antioksidan Dan Kadar Aloin Pada Lidah Buaya. 2020;1:17–24.
44. Biworo A, Budianto WY, Agustina R, Suhartono E. Potensi ADP dan Katalase dalam Ekstrak Air Lidah Buaya (Aloe vera) sebagai Antiinflamasi pada Model Tikus Luka Terkontaminasi Enzymatic Activity of Water Extracts of Aloe vera and It’s Potential as an Anti-Inflammatory in Rats Model of a Wound Contaminate. Mutiara Med [Internet]. 2013;13(1):37–42. Available from: http://journal.umy.ac.id/index.php/mm/article/view/1054