The The Antioxidant Effect of Ajwa Dates (Phoenix dactylifera L.) to Inhibit the Progression of Preeclampsia Threats on Pregnant Women through Malondialdehyde as Prooxidant Serum Marker

  • Ida Royani - Medical Faculty Universitas Muslim Indonesia
  • Nasrudin Andi Mappaware Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Muslim Indonesia, Makassar
  • Nur Rezki Nur Rezki Master of Midwifery, Graduate Program of Hasanuddin University, Makassar
  • Suryani As’ad Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar
Keywords: Ajwa dates;, preeclampsia;, malondialdehyde

Abstract

Hypertension in pregnancy, including preeclampsia, is still a significant problem worldwide and is one of the top three causes of maternal death in Indonesia. The pathophysiology of the disease is unclear yet, but vascular dysfunction due to oxidative stress is thought to play a role. Ajwa dates are known for their antioxidant effects due to their higher phenolic and flavonoids than other dates. The study aimed to determine the impact of consuming seven Ajwa dates each day on the progression of preeclampsia as assessed by changes in malondialdehyde (MDA) levels. Forty pregnant women with gestational age more than 20 weeks were randomly assigned into two groups: the samples of the control group were 10, who were encouraged to consume lots of fruits and vegetables, and the samples of the intervention group were 30, who consumed seven pieces of Ajwa dates every day for eight weeks. MDA measurements were carried out pre-and post-intervention. The intervention group showed a significant reduction in MDA levels following the 8-week intervention period. Consumption of seven Ajwa dates every day can reduce MDA levels significantly and, thus, has the potential to inhibit the progression of preeclampsia in pregnant women who are at risk of preeclampsia based on stress oxidative mechanism.

References

1. WHO | Maternal mortality, 2019. WHO.
2. The American College of Obstetricians and Gynecologists, 2019. ACOG Practice Bulletin No. 202: Gestational Hypertension and Preeclampsia. Obstet. Gynecol. 133, e1–e25. https://doi.org/10.1097/AOG.0000000000003018
3. Turbeville, H.R., Sasser, J.M., 2020. Preeclampsia beyond pregnancy: Long-term consequences for mother and child. Am. J. Physiol.-Ren. Physiol. 318, F1315–F1326. https://doi.org/10.1152/ajprenal.00071.2020
4. Suprihatin, E., Norontoko, D.A., Miadi, 2015. Prediction of Preeclampsia by a Combination of Body Mass Index ( BMI ), Mean Arterial Pressure ( MAP ), and Roll Over Test ( ROT ). Polytech. Heal. Minist. Heal. Surabaya Indonesia.
5. Dsouza, V., Rani, A., Patil, V., Pisal, H., Randhir, K., Mehendale, S., Wagh, G., Gupte, S., Joshi, S., 2016. Increased oxidative stress from early pregnancy in women who develop preeclampsia. Clin. Exp. Hypertens. 38, 225–232. https://doi.org/10.3109/10641963.2015.1081226
6. Kulkarni, A. V., Mehendale, S.S., Yadav, H.R., Kilari, A.S., Taralekar, V.S., Joshi, S.R., 2010. Circulating angiogenic factors and their association with birth outcomes in preeclampsia. Hypertens. Res. 33, 561–567. https://doi.org/10.1038/hr.2010.31
7. Mehendale, S., Kilari, A., Dangat, K., Taralekar, V., Mahadik, S., Joshi, S., 2008. Fatty acids, antioxidants, and oxidative stress in pre-eclampsia. Int. J. Gynecol. Obstet. 100, 234–238. https://doi.org/10.1016/j.ijgo.2007.08.011
8. Hamad, I., Abdelgawad, H., Jaouni, S. Al, Zinta, G., Asard, H., Hassan, S., Hegab, M., Hagagy, N., Selim, S., 2015. Metabolic Analysis of Various Date Palm Fruit (Phoenix dactylifera L.) Cultivars from Saudi Arabia to Assess Their Nutritional Quality 13620–13641. https://doi.org/10.3390/molecules200813620
9. Eid, N.M.S., Al-Awadi, B., Vauzour, D., Oruna-Concha, M.J., Spencer, J.P.E., 2013. Effect of cultivar type and ripening on the polyphenol content of date palm fruit. J. Agric. Food Chem. 61, 2453–2460. https://doi.org/10.1021/jf303951e
10. Nijveldt, R.J., Van Nood, E., Van Hoorn, D.E.C., Boelens, P.G., Van Norren, K., Van Leeuwen, P.A.M., 2001. Flavonoids: A review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr. 74, 418–425. https://doi.org/10.1093/ajcn/74.4.418
11. Panche, A.N., Diwan, A.D., Chandra, S.R., 2016. Flavonoids: An overview. J. Nutr. Sci. 5. https://doi.org/10.1017/jns.2016.41
12. Kumar, S., Pandey, A.K., 2013. Chemistry and Biological Activities of Flavonoids: An Overview. Hindawi Publ. Corp. 2013. https://doi.org/10.1155/2013/162750
13. Malešev, D., Kuntić, V., 2007. Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. J. Serbian Chem. Soc. 72, 921–939. https://doi.org/10.2298/JSC0710921M
14. Procházková, D., Boušová, I., Wilhelmová, N., 2011. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82, 513–523. https://doi.org/10.1016/j.fitote.2011.01.018
15. Khalid, S., Khalid, N., Khan, R.S., Ahmed, H., Ahmad, A., 2017. A review on chemistry and pharmacology of Ajwa date fruit and pit. Trends Food Sci. Technol. 63, 60–69. https://doi.org/10.1016/j.tifs.2017.02.009
16. Soobrattee, M.A., Neergheen, V.S., Luximon-Ramma, A., Aruoma, O.I., Bahorun, T., 2005. Phenolics as potential antioxidant therapeutic agents: Mechanism and actions. Mutat. Res. - Fundam. Mol. Mech. Mutagen. 579, 200–213. https://doi.org/10.1016/j.mrfmmm.2005.03.023
17. Sarwar, M.S., Ahmed, S., Ullah, M.S., Kabir, H., Rahman, G.K.M.M., Hasnat, A., Islam, M.S., 2013. Comparative study of serum zinc, copper, manganese, and iron in preeclamptic pregnant women. Biol. Trace Elem. Res. 154, 14–20. https://doi.org/10.1007/s12011-013-9721-9
18. Akhtar, S., Begum, S., Ferdousi, S., 2011. Calcium And Zinc Deficiency In Preeclamptic Women. J Bangladesh Soc Physiol 6, 94–99.
19. Ma, Y., Shen, X., Zhang, D., 2015. The relationship between serum zinc level and preeclampsia: A meta-analysis. Nutrients 7, 7806–7820. https://doi.org/10.3390/nu7095366
20. Zatollah Asemi, A.E., 2015. The Effect of Multi mineral-Vitamin D Supplementation on Pregnancy Outcomes in Pregnant Women at Risk for Pre-eclampsia. Int. J. Prev. Med. 6
21. Azami, M., Azadi, T., Farhang, S., Rahmati, S., Pourtaghi, K., 2017. The effects of multi mineral-vitamin D and vitamins (C+E) supplementation in the prevention of preeclampsia: An RCT. Int. J. Reprod. Biomed. 15, 273–278. https://doi.org/10.29252/ijrm.15.5.273
22. Hofmeyr, G.J., Lawrie, T.A., Atallah, Á.N., Duley, L., Torloni, M.R., 2014. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst. Rev. 2014. https://doi.org/10.1002/14651858.CD001059.pub4
23. Achamrah, N., Ditisheim, A., 2018. Nutritional approach to preeclampsia prevention. Curr. Opin. Clin. Nutr. Metab. Care 21, 168–173. https://doi.org/10.1097/MCO.0000000000000462
Published
2024-04-24
How to Cite
1.
- IR, Andi Mappaware N, Nur Rezki NR, As’ad S. The The Antioxidant Effect of Ajwa Dates (Phoenix dactylifera L.) to Inhibit the Progression of Preeclampsia Threats on Pregnant Women through Malondialdehyde as Prooxidant Serum Marker. woh [Internet]. 2024Apr.24 [cited 2024May5];:141-7. Available from: https://jurnal.fkmumi.ac.id/index.php/woh/article/view/1324
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