The Relationship Between Nutritional Status And Insulin-Like Growth Factor-1 Levels In Stunted Children In Cirebon Regency
Abstract
Insulin-like Growth Factor-1 (IGF-1) is a growth hormone mediator that acts as a growth-promoting factor in the growth process and is also an indicator of the adaptive immune system. Children who experience stunting will experience obstacles to growth and cognitive and motor development, affecting their productivity as adults. This research aims to determine IGF-1 levels and their relationship with stunted children's nutritional status. The research method used was observational, with a cross-sectional research design. The population of stunted children in the Tegalwangi locus area, Cirebon Regency, a sample of children aged 24-60 months who met the inclusion criteria of not being disabled and not being sick, was 50 children. The research began with parents filling in informed consent. Continue to fill in data on date of birth, measure height and weight, take @1ml of the child's blood, and analyze IGF-1 using the ELISA method. The research results were that the average IGF-1 level for men was 16,812 ± 5,164 ng/ml and for women 13,810 ± 5,111 ng/ml. Average IGF-1 levels aged 24-36 months were 14,777 ± 4,742 ng/ml, 36–48 months 17,050 ± 4,280 ng/ml, and 48–60 months 15,214 ± 6,248 ng/ml. Data analysis using the Pearson correlation test obtained a value of p=0.871 based on age, p=0.047 based on gender, p=0.643 based on Height for age, and p=0.245 based on Weight for age (95% CI). The conclusion is that there is a relationship between the age of a stunted child and IGF-1 levels, and there is no relationship with nutritional status. All stunted children have IGF-1 values below the standard value for normal children based on the literature, namely ≥ 28.54 ng/ml.
References
2. Kelmelnkels RI. (2021). Laulnching Hasil Stuldi Statuls Gizi Indonelsia (SSGI). 1–14.
3. Kelmelnkels RI. (2018). Bulleltin Jelndella Data dan Informasi Kelselhatan: Situlasi Balita Pelndelk di Indonelsia. Kelmelntelrian Kelselhatan RI, 20.
4. Wang, X., Xing, K. H., Qi, J., Gulan, Y., elt al., (2013). Analysis of thel rellationship of insullin-likel growth factor-1 to thel growth vellocity and felelding of helalthy infants. Growth Hormonel & IGF Relselarch, 23(6), 215–219.
5. Hawkels, C. P., & Grimbelrg, A. (2015). Insullin-Likel Growth Factor-I is a Markelr for thel Nultritional Statel. Peldiatric Elndocrinology Relvielws : PElR, 13(2), 499–511.
6. Livingstonel, C. (2012). Thel Insullin-Likel Growth Factor Systelm and Nultritional Asselssmelnt. 2012.
7. Telsselma, M., Gulnaratna, N. S., Broulwelr, I. D., elt al., (2018). Intakel , Selrulm Transthyreltin , Selrulm Amino Acids and Linelar Growth of Childreln in Elthiopia. 1–17.
8. Hossain, M., Chouldhulry, N., Adib, K., elt al., (2017). Elvidelncel-baseld approachels to childhood stulnting in low and middlel incomel coulntriels : a systelmatic relvielw. 903–909.
9. Flora, R.-, Zullkarnain, M.-, Fajar, N. A., elt al., (2021). Kadar Zinc Dan Kadar Igf-1 Selrulm Pada Anak Selkolah Dasar Di Kelcamatan Tulah Nelgelri Kabulpateln Mulsirawas. JPP (Julrnal Kelselhatan Poltelkkels Palelmbang), 16(1), 1–6.
10. Smith, T. J. (2010). Insullin-Likel Growth Factor-I Relgullation of Immulnel Fulnction: A Potelntial Thelrapelultic Targelt in Aultoimmulnel Diselasels? Pharmacological Relvielws, 62(2), 199 LP – 236.
11. Dartelh, El. K. M., Acqulah, El., & Kulmi-Kyelrelmel, A. (2014). Correllatels of stulnting among childreln in Ghana. BMC Pulblic Helalth, 14(1), 504.
12. Tobing, M. L., Panel, M., Harianja, El., elt al., (2021). Tnp2K 2017. PRElPOTIF : Julrnal Kelselhatan Masyarakat, 13(1), 238–244.
13. Tiwari, R., Aulsman, L. M., & Agho, K. El. (2014). Deltelrminants of stulnting and selvelrel stulnting among ulndelr-fivels: elvidelncel from thel 2011 Nelpal Delmographic and Helalth Sulrvely. BMC Peldiatrics, 14(1), 239.
14. Paramita, I. S., Atasasih, H., & ... (2022). Thel Elffelct of Giving Forelst Honely on thel Nultritional Statuls of Stulnting Toddlelrs in Kampar Relgelncy, Riaul Provincel. … Nultrition Joulrnal, 2(1), 33–41.
15. ABCAM. (2018). ElLISA gulidel. ElLISA Gulidel: Elvelrything Youl Neleld to Pelrform Youlr ElLISA Elxpelrimelnts.
16. Biorad. (2017). ElLISA Basics Gulidel. Validation of Pharmacelultical Procelssels, Third Eldition, 42.
17. Pultri, P. N. (2021). Analisis Kadar Insullin-Likel Growth Factor-1 (Igf-1) Pada Anak Delngan Pelrawakan Pelndelk.
18. Trihono, and M. S. (2015). Pelndelk (stulnting) Di Indonelsia, Masalah Dan Solulsinya. Badan Pelnellitian dan Pelngelmbangan Kelselhatan.
19. Bulkulsulba, J., Kaaya, A. N., & Atulkwasel, A. (2017). Preldictors of Stulnting in Childreln Ageld 6 to 59 Months: A Casel–Control Stuldy in Soulthwelst Ulganda. Food and Nultrition Bullleltin, 38(4), 542–553.
20. Condo, J. Ul., Gagel, A., Mock, N., elt al., (2015). Selx diffelrelncels in nultritional statuls of HIV-elxposeld childreln in Rwanda: a longituldinal stuldy. Tropical Meldicinel & Intelrnational Helalth, 20(1), 17–23.
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